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Subsequently extra in vivo techniques were being launched for probing the THC click here induced cannabimimetic outcomes in animals. One particular peculiar product designed usage of a subset of white New Zealand rabbits that exhibited non-lethal convulsions when presented THC acutely and the intensity with the convulsions diminished just after repeated THC administration, i.e., an indication of tolerance enhancement; when THC was discontinued, the animals regained their sensitivity to convulsion proneness (Consroe et al., 1982; Martin and Consroe, 1976). Combining steps of spontaneous website locomotor action applying an open-field arena, rectal temperature recordings, analgesia assessment and indices of immobility (catalepsy) constitutes the cannabinoid tetrad bioassay (Martin et al., 1991). This has long been and nevertheless is Among the most extensively utilised bioassays for examining cannabimimetic exercise in rodents. Each and every of such four endpoints within the tetrad by themselves is not really unique for cannabimimetic action and thus they should be read more evaluated for a cluster rather then independently to diminish the potential risk for detecting Untrue positives (Wiley et al., 2006). This bioassay procedure has exhibited excellent correlation concerning cannabinoid receptor 1 (CB1R) binding affinity and potency (r = 0.
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